Neuroinflammation in Schizophrenia

Schizophrenia is a chronic debilitating mental illness. In many aspects, the neuropathology of schizophrenia closely associated with neuroinflammation, especially microglial activation. Microglial hyperactivity, which characterized by predominant release proinflammatory cytokines serves as basis neuroinflammation hypothesis in schizophrenia. The enhanced inflammatory induce neuronal susceptibility to oxidative stress and trigger, glutamatergic synaptic dysregulation, mesolimbic mesocortical pathways. Many vitro studies, vivo animal evidence, post-mortem examinations, neuroimaging evaluations Positron Emission Tomography (PET), anti-inflammatory antipsychotic use converge upon central role activation common features